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The undifferentiated nucleotide specificities of sure archaeal ligases have tantalizing implications for enzyme evolution and the possible use of ADP as being a substrate by ancestors of modern DNA ligases. The power of some archaeal ligases to make the most of ATP and NAD+ or ATP and ADP as substrates is likely to be stated whenever they recognized just the ADP part widespread to all 3 nucleotides.
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S3), but the topology on the LigA clamp is starkly unique from that of your clamps fashioned by ChVLig and HuLig1. The kissing contacts that near the LigA clamp are sui generis
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